The role of osteopontin in the induction of the CD40 ligand in Graves' disease.

TitleThe role of osteopontin in the induction of the CD40 ligand in Graves' disease.
Publication TypeJournal Article
Year of Publication2014
AuthorsQi Y, Li X, Ma X, Xu L, Zhang X, Jiang X, Hong J, Cui B, Ning G, Wang S
JournalClinical endocrinology
Volume80
Issue1
Pagination128-34
Date Published2014 Jan
Abstract

Graves' disease (GD) is a common autoimmune disease involved autoantibody production. Although we previously reported that osteopontin (OPN), a proinflammatory protein, affected development of GD through NF-κB activation, little is known about the role of OPN in regulating immunoglobulin production in GD. CD40 Ligand (CD40L) is expressed on the surface of activated CD4+T cells and costimulates CD40 on B cells, stimulating production of immunoglobulins, a process which has been reported to play a vital role in immunological signalling transduction in several autoimmune diseases. This study sought to characterize the relationship between CD40L and GD development, as well as investigating the role of OPN in modulating immunoglobulin production in GD via CD40L.

DOI10.1039/c3an01929b
Alternate JournalClin. Endocrinol. (Oxf)