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Selective Methylation of Amines with Carbon Dioxide and H2.
|Title||Selective Methylation of Amines with Carbon Dioxide and H2.|
|Publication Type||Journal Article|
|Year of Publication||2013|
|Authors||Li Y, Sorribes I, Yan T, Junge K, Beller M|
|Journal||Angewandte Chemie (International ed. in English)|
|Date Published||2013 Sep 25|
Put a label on it: Carbon dioxide with H2 is shown to be an efficient and selective methylation reagent for aromatic and aliphatic amines (see scheme; acac=acetylacetonate, triphos = 1,1,1-tris(diphenylphosphanylmethyl)ethane). A variety of functionalized amines including (13) C-labelled drugs were obtained with good yields and functional-group tolerance.
|Alternate Journal||Angew. Chem. Int. Ed. Engl.|