Selective Methylation of Amines with Carbon Dioxide and H2.

TitleSelective Methylation of Amines with Carbon Dioxide and H2.
Publication TypeJournal Article
Year of Publication2013
AuthorsLi Y, Sorribes I, Yan T, Junge K, Beller M
JournalAngewandte Chemie (International ed. in English)
Date Published2013 Sep 25
Abstract

Put a label on it: Carbon dioxide with H2 is shown to be an efficient and selective methylation reagent for aromatic and aliphatic amines (see scheme; acac=acetylacetonate, triphos = 1,1,1-tris(diphenylphosphanylmethyl)ethane). A variety of functionalized amines including (13) C-labelled drugs were obtained with good yields and functional-group tolerance.

DOI10.1371/journal.pone.0077156
Alternate JournalAngew. Chem. Int. Ed. Engl.