Serum levels of neuron-specific ubiquitin carboxyl-terminal esterase-L1 predict brain injury in a canine model of hypothermic circulatory arrest.

TitleSerum levels of neuron-specific ubiquitin carboxyl-terminal esterase-L1 predict brain injury in a canine model of hypothermic circulatory arrest.
Publication TypeJournal Article
Year of Publication2011
AuthorsArnaoutakis GJ, George TJ, Wang KK, Wilson MA, Allen JG, Robinson CW, Haggerty KA, Weiss ES, Blue ME, Talbot CC, Troncoso JC, Johnston MV, Baumgartner WA
JournalThe Journal of thoracic and cardiovascular surgery
Volume142
Issue4
Pagination902-910.e1
Date Published2011 Oct
Abstract

Ubiquitin carboxyl-terminal esterase-L1 (UCHL1) is a protein highly selectively expressed in neurons and has been linked to neurodegenerative disease in humans. We hypothesize that UCHL1 would be an effective serum biomarker for brain injury as tested in canine models of hypothermic circulatory arrest (HCA) and cardiopulmonary bypass (CPB).

DOI10.1016/j.jtcvs.2011.06.027
Alternate JournalJ. Thorac. Cardiovasc. Surg.