SNOMAD (Standardization and NOrmalization of MicroArray Data): web-accessible gene expression data analysis.

TitleSNOMAD (Standardization and NOrmalization of MicroArray Data): web-accessible gene expression data analysis.
Publication TypeJournal Article
Year of Publication2002
AuthorsColantuoni C, Henry G, Zeger S, Pevsner J
JournalBioinformatics (Oxford, England)
Volume18
Issue11
Pagination1540-1
Date Published2002 Nov
Abstract

SNOMAD is a collection of algorithms for the normalization and standardization of gene expression datasets derived from diverse biological and technological sources. In addition to conventional transformations and visualization tools, SNOMAD includes two non-linear transformations which correct for bias and variance which are non-uniformly distributed across the range of microarray element signal intensities: (1). Local mean normalization; and (2). Local variance correction (Z-score generation using a locally calculated standard deviation).

Alternate JournalBioinformatics