Spinal cord quantitative MRI discriminates between disability levels in multiple sclerosis.

TitleSpinal cord quantitative MRI discriminates between disability levels in multiple sclerosis.
Publication TypeJournal Article
Year of Publication2013
AuthorsOh J, Saidha S, Chen M, Smith SA, Prince J, Jones C, Diener-West M, van Zijl PCM, Reich DS, Calabresi PA
JournalNeurology
Volume80
Issue6
Pagination540-7
Date Published2013 Feb 5
Abstract

The clinicoradiologic paradox, or disconnect between clinical and radiologic findings, is frequently encountered in multiple sclerosis (MS), particularly in the spinal cord (SC), where lesions are expected to cause clinical impairment. We aimed to assess whether quantitative diffusion tensor and magnetization transfer imaging measures in the SC can distinguish MS cases of comparable lesion burdens with high and low disability.

DOI10.1039/c3cc44249g
Alternate JournalNeurology