Straightforward synthesis of alpha,beta-unsaturated thioesters via ruthenium-catalyzed olefin cross-metathesis with thioacrylate.

TitleStraightforward synthesis of alpha,beta-unsaturated thioesters via ruthenium-catalyzed olefin cross-metathesis with thioacrylate.
Publication TypeJournal Article
Year of Publication2008
Authorsvan Zijl AW, Minnaard AJ, Feringa BL
JournalThe Journal of organic chemistry
Volume73
Issue14
Pagination5651-3
Date Published2008 Jul 18
Abstract

The cross-metathesis reaction of S-ethyl thioacrylate with a variety of olefins is effectively catalyzed by using a ruthenium benzylidene olefin metathesis catalyst. This reaction provides a convenient and versatile route to substituted alpha,beta-unsaturated thioesters, key building blocks in organic synthesis.

DOI10.1021/jo800879e
Alternate JournalJ. Org. Chem.