Suppression of lipid artifacts in amide proton transfer imaging.

TitleSuppression of lipid artifacts in amide proton transfer imaging.
Publication TypeJournal Article
Year of Publication2005
AuthorsSun PZ, Zhou J, Sun W, Huang J, van Zijl PCM
JournalMagnetic resonance in medicine : official journal of the Society of Magnetic Resonance in Medicine / Society of Magnetic Resonance in Medicine
Volume54
Issue1
Pagination222-5
Date Published2005 Jul
Abstract

Amide proton transfer (APT) imaging is a type of chemical exchange saturation transfer imaging in which the amide protons of cellular proteins and peptides are saturated and detected via the water resonance. To study this effect, conventional magnetization transfer and direct saturation effects in the frequency-dependent water saturation spectrum (z-spectrum) need to be removed by asymmetry analysis with respect to the water frequency offset. When using echo planar imaging, it was found that unequal pericranial fat saturation at equidistant higher and lower frequencies with respect to water leads to a lipid artifact in APT asymmetry images. It is demonstrated that a chemical-shift-selective refocusing pulse in combination with crusher gradients can suppress this artifact and provide high-quality images.

Alternate JournalMagn Reson Med