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Synthesis of optically active bifunctional building blocks through enantioselective copper-catalyzed allylic alkylation using Grignard reagents.
|Title||Synthesis of optically active bifunctional building blocks through enantioselective copper-catalyzed allylic alkylation using Grignard reagents.|
|Publication Type||Journal Article|
|Year of Publication||2007|
|Authors||van Zijl AW, López F, Minnaard AJ, Feringa BL|
|Journal||The Journal of organic chemistry|
|Date Published||2007 Mar 30|
Enantioselective copper-catalyzed allylic alkylations were performed on allylic bromides with a protected hydroxyl or amine functional group using several Grignard reagents and Taniaphos L1 as a ligand. The terminal olefin moiety in the products was transformed into various functional groups without racemization, providing facile access to a variety of versatile bifunctional chiral building blocks.
|Alternate Journal||J. Org. Chem.|