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Targeting the c-Met pathway potentiates glioblastoma responses to gamma-radiation.
|Title||Targeting the c-Met pathway potentiates glioblastoma responses to gamma-radiation.|
|Publication Type||Journal Article|
|Year of Publication||2005|
|Authors||Lal B, Xia S, Abounader R, Laterra J|
|Journal||Clinical cancer research : an official journal of the American Association for Cancer Research|
|Date Published||2005 Jun 15|
Resistance to current cytotoxic therapies limits the treatment of most solid malignancies. This results, in part, from the overactivation of receptor tyrosine kinases and their downstream pathways in tumor cells and their associated vasculature. In this report, we ask if targeting the multifunctional mitogenic, cytoprotective, and angiogenic scatter factor/hepatocyte growth factor (SF/HGF)/c-Met pathway potentiates antitumor responses to gamma-radiation.
|Alternate Journal||Clin. Cancer Res.|