Volutrauma, but not Atelectrauma, Induces Systemic Cytokine Production by Lung-Marginated Monocytes*.

TitleVolutrauma, but not Atelectrauma, Induces Systemic Cytokine Production by Lung-Marginated Monocytes*.
Publication TypeJournal Article
Year of Publication2014
AuthorsWakabayashi K, Wilson MR, Tatham KC, O'Dea KP, Takata M
JournalCritical care medicine
Volume42
Issue1
Paginatione49-57
Date Published2014 Jan
Abstract

Ventilator-induced lung injury has substantive impact on mortality of patients with acute respiratory distress syndrome. Although low tidal volume ventilation has been shown to reduce mortality, clinical benefits of open-lung strategy are controversial. In this study, we investigated the impact of two distinct forms of ventilator-induced lung injury, i.e., volutrauma and atelectrauma, on the progression of lung injury and inflammation, in particular alveolar and systemic cytokine production.

DOI10.1155/2013/781024
Alternate JournalCrit. Care Med.