Clinical Research Projects

Addressing Sleep Problems in Children with Autism Spectrum Disorder at Multidisciplinary Autism Centers
Principal Investigator: Accardo, Jennifer
Sleep problems are highly prevalent among children with autism spectrum disorders (ASD), particularly insomnia. Pediatric sleep problems are often overlooked in typically-developing children. It is...
Problem Sleep in Children and Young Adults with Fragile X Syndrome with and without Autism Spectrum Disorder
Principal Investigator: Accardo, Jennifer
This study will examine relationships between sleep difficulty and autism in boys and young men with full mutation Fragile X syndrome (FXS). This study will analyze retrospective cross-sectional data...
Sleep disturbances in neurobehaviorally challenged children with sickle cell disease: A pilot study
Principal Investigator: Accardo, Jennifer
This study aims to evaluate sleep in a sample of children, adolescents, and young adults with SCD referred for neurobehavioral evaluation for academic and cognitive difficulties. We will further test...
Use of an Educational Story to Prepare Children with Developmental Disabilities for Overnight Polysomnography
Principal Investigator: Accardo, Jennifer
We hypothesize that use of an educational story with pictures illustrating overnight polysomnography procedure accompanied by simple narrative will be a cost-effective, readily accepted intervention...
Sleep Phenotypes in Children
Principal Investigator: Accardo, Jennifer
Children have a high prevalence of sleep problems and disorders. The current study will be a retrospective record review of clinic records from a subspecialty sleep medicine clinic staffed by a child...
Study of the Relationship Between Preferences for High Fat Food Items and Ketogenic and Modified Atkins Diet Efficacy Among Children with Seizure Disorders
Principal Investigator: Amari, Adrianna
Although highly effective for the treatment of intractable epilepsy, the ketogenic diet is not always included in the treatment option hierarchy presented to families, in part due to perceptions that...
Neuroimaging and Neurobehavioral Outcomes of Pediatric Neuromyelitis Optica: A Pilot Study
Principal Investigator: Arenivas, Ana
The primary objective of this proposed prospective pilot study, entitled “Neuroimaging and Neurobehavioral Outcomes of Pediatric Neuromyelitis Optica: A Pilot Study” is to determine the utility of...
Locomotor Training for Neurological Disease
Principal Investigator: Bastian, Amy
For this pilot study our aims are to:  Understand basic brain mechanisms of inter-limb control and adaptation during locomotion to determine the paradigm to be used for improving interlimb...
Neural Control of Reaching
Principal Investigator: Bastian, Amy
Aim1: Use dynamic computational models of the human arm and a robot exoskeleton to investigate the mechanisms of cerebral versus cerebellar coordination deficits.  Cerebral coordination deficits...
Locomotor Control and Learning
Principal Investigator: Bastian, Amy
In this project, we will study split belt treadmill walking and walking under natural conditions. We have found that adaptation to split belt walking in adults and children varies in its...
Cerebellar Control of Movement
Principal Investigator: Bastian, Amy
Cerebellar damage disrupts movement coordination. Actions ranging from walking to reaching become inaccurate and difficult to control, which has deleterious effects on most functional movements....
Long Term Split Belt Training for Stroke Recovery
Principal Investigator: Bastian, Amy
We recently discovered that the walking deficits of people with post-stroke hemiparesis can be improved on short timescales by adaptation to split-belt treadmill conditions that exaggerate the...
FIRST-STIM CNS Growth Factor Release and Changes in the Inflammatory Environment in Response to Electrical Stimulation in Subjects with Inflammatory Myelopathies
Principal Investigator: Becker, Daniel
A Phase II Randomized, Single-Blinded, 100-Subject Clinical Trial of Functional Electrical Stimulation in the Treatment of Inflammatory Myelopathies The specific aims of the proposal are: To...
Crisis Management in a Special Education School: Trends in the Use of Restraint and Seclusion to Maintain Safety
Principal Investigator: Beetar, John
This study is a description of trends in the occurrence and duration of restraint and seclusion in the lower/middle school and high school of Kennedy Krieger School Programs. Seven years of crisis...
Yoga Based Movement Therapy Study
Principal Investigator: Belcher, Harolyn
This preliminary study will examine the feasibility of conducting a randomized clinical trial of Yoga Based Movement Therapy (YBMT)and standard care mental health (SCMH) treatment compared to SCMH...
NCTSI Cross-Site Evaluation Component 1 and 2
Principal Investigator: Belcher, Harolyn
What are the descriptive and clinical outcomes of 25 children treated at KKFC? Child-Caregiver dyads treated at KKFC will be assessed at baseline, three-months, six-months, nine-months and 12-months...
FamilyLive Feasibility and Effectiveness Study
Principal Investigator: Belcher, Harolyn
Children who have been exposed to neglect often have parents who experienced their own childhood neglect and/or trauma (defined as childhood physical, sexual or emotional abuse, exposure to life...
National Child Traumatic Stress Network (NCTSN) Quality Improvement Initiative Database
Principal Investigator: Belcher, Harolyn
The proposed study is to request permission to continue federally mandated data collection to examine the clinical outcomes of children at the Family Center at Kennedy Krieger Institute who are...
KKI TFC KIDnet Outcome Monitoring System
Principal Investigator: Belcher, Harolyn
The KIDnet system is a clinical needs assessment, functional outcome measure, and therapeutic effectiveness database used by the State of Maryland and clinical foster care providers (Kennedy Krieger...
Strengthening Families' Coping Resources Open Trial
Principal Investigator: Belcher, Harolyn
This study is an open trial to determine the effectiveness of the Strengthening Family Coping Resources (SFCR) clinical treatment for children and families affected by trauma exposure. The clinicians...
RISE: Promoting Diversity among Public Health Professionals
Principal Investigator: Belcher, Harolyn
This IRB proposal is to obtain permission to publish the outcome results of a student training program to promote public health careers among under-represented graduate students. All data have been...
MCHC/RISE-UP and Ferguson Fellowship Program Evaluation
Principal Investigator: Belcher, Harolyn
The proposed study is an federally mandated evaluation of two CDC-funded public health training programs. The overarching goal is of the programs is to increase the diversity of the public health...
Leadership Behaviors of Health Professionals and the Associations with Knowledge, Attitudes, and Practices Related to Health Promotion for Individuals with Developmental Disabilities
Principal Investigator: Belcher, Harolyn
The study was completed under protocol: NA_00014866. There will be no change in questions, plan or new data collection. Reactivating study to analyze the data previously collected and for manuscript...
Urinary Tract Infection in Kennedy Krieger Institute Patients
Principal Investigator: Belcher, Harolyn
Urinary tract infections (UTI) are one of the most common bacterial infections (Schappert & Rechtsteiner, 2008; Litwin et al., 2005). Data from the National Ambulatory Medical Care Survey...
The Garden of Hope: Horticultural Therapy with Traumatized Children
Principal Investigator: Belcher, Harolyn
The Garden of Hope: Horticultural Therapy with Traumatized Children (HTTC) study will evaluate the effectiveness of horticultural therapy as an adjunct therapy to standard mental health treatment for...
TF-CBT Effectiveness Study
Principal Investigator: Belcher, Harolyn
Trauma Focused Cognitive Behavior Therapy (TF-CBT) is an evidence-based mental health treatment designed for children who have experienced traumatic life events. Children at the Kennedy Krieger...
KKI Benchmark TFC
Principal Investigator: Belcher, Harolyn
The Kennedy Krieger Institute (KKI) Benchmark Treatment Foster Care (TFC) evaluation study will collect program evaluation and patient demographic, treatment and eight outcome measures on the KKI TFC...
KKFC Children at Risk Study
Principal Investigator: Belcher, Harolyn
This study is designed to evaluate the association between parental risk factors and child behavior and parental stress following six months of mental health treatment. The study will use data from a...
The Baltimore Behavioral Enhancement through Training & Teaching to Expand Resiliency (BETTER) Family & Community Partnership
Principal Investigator: Belcher, Harolyn
Does Head Start Center-based mental health and substance abuse prevention intervention improve parent, child, and family outcomes (e.g. child behavior, parent stress and mental health, family...
Relationship of Cortical MRI to ASIA Impairment Scale in Chronic Spinal Cord Injury
Principal Investigator: Belegu, Visar
Preliminary data suggests that spinal cord and sensorimotor cortical function is disrupted following SCI and individuals with SCI have a different pattern of brain activation compared to individuals...
The Use of Naturally Occurring Schedules of Reinforcement to Decrease Inappropriate Mealtime Behavior: Are General Recommendations Enough?
Principal Investigator: Borrero, Carrie
The primary objective of this research is to determine if an approximation of natural schedules of reinforcement (observed during caregiver-fed meals with children) can be approximated through the...
A Comparison of Two Physical Guidance Procedures in the Treatment of Pediatric Food Refusal
Principal Investigator: Borrero, Carrie
Escape prevention procedures implemented in the treatment of food refusal may vary across clinical settings. An evidence base exists for at least one form of physical guidance that is commonly...
Conceptualizing Food Preferences as Rich-to-Lean and Lean-to-Rich Transitions: A Translational Analysis
Principal Investigator: Borrero, Carrie
The purpose of this study is to determine if a children's food preferences following treatment for pediatric food refusal continue to impact mealtimes. During meals, typically multiple foods are...
An Evaluation of Noncontingent Reinforcement and Differential Reinforcement with Escape Extinction in the Treatment of Food Refusal
Principal Investigator: Borrero, Carrie
This study is a retrospective record review of former patients on the Pediatric Feeding Disorder Unit at Kennedy Krieger Institute. The primary objective of this study is to compare effects of escape...
Descriptive Analyses of emesis and an experimental evaluation of the effects of NCR on emesis
Principal Investigator: Borrero, Carrie
Pediatric feeding disorders can result in severe consequences such as growth failure. Feeding disorders are also associated with a wide range of different types of refusal. Food refusal can include...
Some Effects of Caregiver Integrity Given the Initiation of Training
Principal Investigator: Borrero, Carrie
Behavioral treatment of pediatric feeding disorders focuses on weakening or eliminating environmental contingencies that support food refusal. Previous descriptive research evaluating parent-child...
The Use of Video Modeling via an iPad to Increase Independence with Vocational Tasks for Students with Autism
Principal Investigator: Brandenburg, Linda
The purpose of this study is to employ a single-case reversal research design (ABAB) to evaluate the effectiveness of using video modeling procedures by means of an iPad to increase independent task...
Fragile X Clinical and Research Cooperative Consortium Registry and Repository
Principal Investigator: Budimirovic, Dejan
This project will advance the core activities of the Fragile X Clinical and Research Consortium (FXCRC). The FXCRC is a collaborative endeavor initiated in 2006 by the National Fragile X Foundation (...
Early Communicative Functions and Later Autism
Principal Investigator: Budimirovic, Dejan
This study is a de-identified retrospective review of previously collected clinical data. The aim of the study is to compare acquisition of early communication skills between individuals with fragile...
High Resolution FMR1 Genetic and Epigenetic Molecular Assessments in a Well Characterized Cohort of Full Mutation and Premutation Fragile X Patients
Principal Investigator: Budimirovic, Dejan
The fragile X gene, FMR1, is critical for brain development and has many markers. Syndromic autism spectrum disorder (ASD) is common in males with an FMR1 full mutation (FM, >200 CGG). Yet males...
Neuropsychiatric Disorder in Young Adults with Down Syndrome
Principal Investigator: Capone, George
We propose to consecutively enroll new patients presenting to our clinic for initial clinical evaluation of neuropsychiatric and behavioral problems. Our goal is to 1) quantify psychiatric and...
A 20-Week Double Blind Placebo Controlled Clinical Trial to Evaluate the Safety and Efficacy of Rivastigmine in Children (ages 10-17) with Down syndrome
Principal Investigator: Capone, George
The specific aims of this study are to: a) investigate short-term safety and efficacy of rivastigmine treatment; b) build upon the open-label treatment results of overall function and language...
Autism Spectrum Disorder in Down Syndrome: A Model of Repetitive and Stereotypic Behavior for Idiopathic ASD
Principal Investigator: Capone, George
The proposed project will be an initial delineation of the distinctive and specific features of Down syndrome (DS) and co-morbid autism spectrum disorder (DS + ASD). The primary focus is on the...
Depression and Sleep Disorders in Adolescents and Young Adults with Down Syndrome
Principal Investigator: Capone, George
Persons with Down syndrome (DS) are known to exhibit adolescent and adult-onset psychopathology such as depression, anxiety, obsessive-compulsive and schizophreniform disorders. Many also have...
A 4-Week Randomized, Double-Blind, Placebo-Controlled, Phase 2a Safety and Pharmacokinetic Study of Oral ELND005 in Young Adults With Down Syndrome Without Dementia
Principal Investigator: Capone, George
This is a prospective, randomized, double-blind, placebo-controlled, parallel-group, three-arm, multicenter study of the safety and PK of ELND005 administered orally for 4 weeks. Safety (eg, AEs,...
Therapeutic Hypothermia After Pediatric Cardiac Arrest: The THAPCA Trials (Telephone Follow Up Center)
Principal Investigator: Christensen, James
Cardiac arrest in childhood often results in death or poor quality neurologic survival. Out-of-hospital cardiac arrest in children is usually preceded by respiratory failure and hypoxia, whereas in-...
Improving Teacher Effectiveness in Classrooms for Students with Autism Spectrum Disorders
Principal Investigator: Church, Robin
Standard practice in educational settings includes teacher evaluation by administrators to provide feedback about the quality of programming in their classrooms. This data is then used to improve a...
Innovative approaches to gauge neurologic progression in Sturge-Weber syndrome
Principal Investigator: Comi, Anne
This 1 of three projects funded by a NIH consortium grant to study Sturge-Weber syndrome (SWS). It will create a national database, determine if urine biomarkers can predict neurologic progression in...
Multidiciplinary Protocol to Address the Pathophysiology of Sturge-Weber Syndrome
Principal Investigator: Comi, Anne
The Multidisciplinary Protocol to Address the Pathophysiology of Sturge-Weber Syndrome's goal is to better understand how Sturge-Weber Syndrome affects the brain, eyes, skin, blood vessels, behavior...
Qualitative interviews and focus groups with military-connected parents
Principal Investigator: Crockett, Jennifer
What do military families identify as key considerations and barriers in seeking treatment for their children with emotional and behavioral challenges? Our plan is to conduct individual interviews...
Behavioral Persistence: Basic, Translational, and Clinical Studies
Principal Investigator: DeLeon, Iser
Clinical applications of reinforcement-based treatments for problem behavior in persons with intellectual and developmental disabilities reduce the frequency of problem behavior by reinforcing an...
Behavioral Economics in MR/DD and Behavior Disorders (2)
Principal Investigator: DeLeon, Iser
Assessments of severe behavior disorders of children with intellectual and developmental disabilities (IDD) have revealed that behavior problems are often maintained by their functional outcomes (or...
Translational Analyses of Chronic Aberrant Behavior Across the Lifespan
Principal Investigator: DeLeon, Iser
The goal of the proposed line of research is to gain a better understanding of the processes that evoke and maintain severe problem behavior (i.e., chronic aberrant behavior) in persons with...
Diffusion Tensor Imaging and Reading Disabilities
Principal Investigator: Denckla, Martha
We intend to test the hypothesis that DTI parameters will reveal abnormalities in fiber bundle architecture in the perisylvian region of children with RD, and that these DTI changes will be...
Electrophysiological Studies of Attention and Perception
Principal Investigator: Ewen, Joshua
This protocol is designed to allow for the recruitment of healthy adult volunteers in order to perform studies of attention and perception in human cognition. The primary purpose of this data...