Anomalus Motor Physiology in ADHD

Principal Investigator: Stewart Mostofsky

The hypothesis of this study is that the neuromotor anomalies present in children with ADHD will be associated with deficient intracortical and interhemispheric inhibition of the motor cortex. This hypothesis is consistent with studies suggesting that the central deficit of ADHD is a failure to inhibit or delay a behavioral response. This study will use motor examination, single and paired pulse transcranial magnetic stimulation (TMS), and fMRI to test this hypothesis. Our preliminary studies using fMRI and TMS suggest that abnormalities of motor cortex inhibition are present in children with ADHD. The ability to detect abnormalities within these cortical systems will provide further evidence of a neurobiological pathogenesis of ADHD and may provide a biological marker for the behavioral abnormalities that are characteristic of ADHD. The data from these studies will yield critical insights into the neurobiological basis of the disorder and will also set the stage for future development of more effective therapies for this population.