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Effect of glycerol trierucate on clinical course of Adrenoleukodystrophy
Adrenoleukodystrophy is a disorder of very long chain fatty acids secondary to defects in peroxisomal beta oxidation. The accumulation of these fatty acids results in a disorder of the adrenal glands and myelin. A restricted diet and the use of a compound containing glycerol trierucate has been shown to lower very long chain fatty acids.
This study which began in 1988 is attempting to investigate the preventative effect of lowering very long chain fatty acids.