Interrelationships among quantitative measures of white matter injury, sensorimotor function and learning profiles in children with cerebral palsy

Principal Investigator: Alexander Hoon

Injury to white matter pathways is strongly associated with the severity of spastic diplegia in children born preterm. In previous research, we have shown that there is preferential injury in sensory pathways than in descending cortiocspinal tracts, and that this injury pattern is associated with sensorimotor impairment in a small group of children. The goal of this study is to correlate Diffusion Tensor Imaging (DTI) and Magnetization Transfer (MT)derived measures of white matter integrity with locomotor and neuropsychological function.