Neural basis of impairments in response inhibition and processing speed following pediatric traumatic brain injury

Principal Investigator: Stacy Suskauer

Impairments in response inhibition and processing speed developing after pediatric traumatic brain injury (TBI) are common and affect behavioral and academic outcomes. It remains unclear which brain structures, when injured in childhood TBI, are responsible for impaired response inhibition and processing speed. This goals of this study are to further characterize impairments in response inhibition and processing speed following pediatric TBI and to identify areas of injury to the brain which are associated with resulting impairment in response inhibition and processing speed. In order to achieve these goals, a cohort of children with TBI will complete a series of laboratory tasks designed to test response inhibition under varying cognitive and behavioral demands and will undergo neuropscyhological testing including evaluation of processing speed. In addition, each child's parent will complete a series of questionnaires regarding their child's behavior. Sensitive MRI techniques will be used to acquire data regarding areas of white and gray matter injury for each child, such that correlations between area of brain injury and measures of response inhibition and processing speed can be identified. Typically developing children and children with ADHD will be studied as comparison populations.

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