Relation of HDL levels with home based Activity Based Restorative Therapies in spinal cord injured adults

Principal Investigator: Cristina Sadowsky

Hypothesis: HDL levels increase following home based Activity Based Restorative Therapies (ABRT)

The effect of exercise on lipid profile is well documented in the able bodied population. The effect of exercise on lipid profile in individuals with Spinal Cord Injury (SCI) is less clear. The evidence on the effects of exercise on lipid and carbohydrate metabolism disorders is of poor quality and inconclusive in findings. Studies to date have been short in duration, have involved few subjects, and have relied on study designs highly susceptible to error. 

At our center, the International Center for Spinal Cord Injury, we have seen a significant number of individuals with spinal cord dysfunction over the past four years since opening. We specialize in delivering long term (and mostly home based) activity based restorative therapies (ABRT) that are predicted to improve lipid profile abnormalities. ABRT consists of maintaining activity below the level of neurologic injury. This is achieved by delivering a customized set of therapeutic interventions consisting of Functional Electrical Stimulation (FES) assisted ergometry, strengthening, and sensory stimulation in a (mostly) home based setting. Individuals are seen before initiation of therapy and throughout the long-term delivery of interventions. The amount of FES ergometry performed is monitored and quantified electronically as part of routine clinical care. Also as part of routine clinical care, we monitor lipid profile on an annual basis. We intend to review records and collect information including laboratory data of fasting lipid profile before and following 1 year of ABRT. We will also record age, ethnicity, visit date, etiology and severity of spinal cord injury based on American Spinal Injury Association (ASIA) classification, and amount of performed FES ergometry. We are only reviewing charts of our own clinical patients, no additional clinical testing is performed outside the routine clinical care