Retrospective Review of Extrinsic Factors Associated with Changes in Clinical Status of Patients with Mitochondrial Disorders

Principal Investigator: Richard Kelley

The specific aims of this retrospective study in patients with known primary mitochondrial disorders are: 

  1. To determine which recommended immunizations have been given to patients with known primary mitochondrial disorders and at what age.
  2. To determine if patients with primary mitochondrial disorders who received immunizations experienced adverse events following immunization (AEFIs) at rates higher than those reported in the general population.
  3. To compare the characteristics of patients with known primary mitochondrial disorders who experienced AEFIs with patients with known primary mitochondrial disorders who did not experience AEFIs after receiving similar vaccines.
  4. To determine whether metabolic decompensation occurs in these patients more frequently following immunization than after other clinical events (i.e. infections, etc.) or at times unrelated to immunizations.
  5. To describe the occurrence of vaccine-preventable diseases in study patients or worsening of clinical or laboratory parameters associated with vaccine preventable diseases. 

We will achieve these aims by conducting a retrospective review of the medical records of patients with mitochondrial diseases managed by the Kennedy Kreiger Institute and 5 other Clinical Immunization Safety Assessment (CISA) centers at Northern California Kaiser Permanente, Stanford University, Vanderbilt University, Boston University, and Columbia University.