Funded Research Projects

Mechanisms and Rehabilitation of Cerebellar Ataxia
Principal Investigator: Bastian, Amy
Sponsored by the National Institutes of Health -- 2R01HD040289. Cerebellar damage disrupts movement coordination. Actions ranging from walking to reaching become inaccurate and difficult to control,...
Human Locomotor Plasticity in Health and Disease
Principal Investigator: Bastian, Amy
Sponsored by the National Institutes of Health -- 5R01HD048741-06. Walking patterns can adapt on short timescales (minutes to hours) to temporary conditions, such as icy sidewalks. They can also...
The Development of a Reading Intervention for Deaf and Hard-of-Hearing Students
Principal Investigator: Beetar, John
The specific aim of this project is to complete the development of a computer software program of reading instruction, Sign 'n' Read, for deaf and hard-of-hearing students. Presently in development...
Kennedy Krieger Family Center - Integrated Trauma Approaches
Principal Investigator: Belcher, Harolyn
The goals of the Kennedy Krieger Family Center Trauma Intervention Program (TIP) are to: Evaluate the feasibility and effectiveness of evidence-based treatment protocols, endorsed by the National...
Maternal Child Health Careers/Research Initiatives -- Undergraduate Program
Principal Investigator: Belcher, Harolyn
Sponsored by DHHS/CDC -- 1U50MN000025. Healthy People 2020 highlights the importance of eliminating health disparities and increasing the quality and years of healthy life free of preventable disease...
A 12 Week Double Blind Placebo Clinical Trial to Evaluate the Safety and Efficacy of Rivastigimine in Children with Down Syndrome
Principal Investigator: Capone, George
Individuals with Down syndrome (DS) exhibit a notable cholinergic deficiency by the 4th decade of life. It is unclear how early in life presynaptic cholinergic deterioration begins or how it evolves...
Intellectual and Developmental Disabilities Research Centers 2008
Principal Investigator: Cataldo, Michael
This application for continued support of Years 21 through 25 of the Mental Retardation and Developmental Disabilities Research Center (MRDDRC) at the Kennedy Krieger Institute and Johns Hopkins...
Developing a Means of Comparing Expenditures at Three Models of Nonpublic Special Education Services at a Private Special Education School in Baltimore, Maryland
Principal Investigator: Church, Robin
Currently, there is no uniform means of determining the true cost of nonpublic special education in Maryland. Today, tuition is used as “the cost” of providing these programs. The proposed project...
Anticonvulsants, Ischemic Seizures and Regeneration in the Immature Brain
Principal Investigator: Comi, Anne
Neonatal stroke affects one in 4000 term births and frequently results in cognitive impairments. Neonatal strokes present with seizures, and anticonvulsants (usually phenobarbital) are administered...
Behavioral Economics in MR/DD and Behavior Disorders (2)
Principal Investigator: DeLeon, Iser
Assessments of severe behavior disorders of children with intellectual and developmental disabilities (IDD) have revealed that behavior problems are often maintained by their functional outcomes (or...
Translational Analyses of Chronic Aberrant Behavior Across the Lifespan
Principal Investigator: DeLeon, Iser
The goal of the proposed line of research is to gain a better understanding of the processes that evoke and maintain severe problem behavior (i.e., chronic aberrant behavior) in persons with...
EEG-Based Assessment of Functional Connectivity in Autism
Principal Investigator: Ewen, Joshua
Sponsored by the National Institutes of Health -- 1K23NS073626-01. There are substantial data to suggest that altered cerebral connectivity is a key aspect of the neurobiology of autism. Nevertheless...
Study of White Matter Development in a Rodent Model of Perinatal Brain Injury
Principal Investigator: Fatemi, S. Ali
This is a Mentored Clinical Scientist Research Career Development Award allowing Dr. Fatemi to develop a career as an independent investigator in the field of translational neuroscience research,...
Comprehensive Long-Term Evaluation of the Gunn Rat Kernicterus Model
Principal Investigator: Fatemi, Seyed A.
The proposed project is the initial phase of a long-term endeavor to develop therapies that will help patients with dyskinetic cerebral palsy related to mitochondrial dysfunction and a Kernicterus-...
Mentored Clinical Scientist Research Career Development Award
Principal Investigator: Fatemi, Seyed A.
The proposed training will prepare a young pediatric neurology faculty member for a career as an independent investigator in the field of translational neuroscience research, focusing on perinatal...
An adaptive, phase IIB/III, double-blind, randomized, placebo-controlled, multi-center study of the safety and efficacy of NaBen® (sodium benzoate), a d-amino acid oxidase inhibitor, as an add-on treatment for schizophrenia in adolescents
Principal Investigator: Findling, Robert
Phase IIb Objectives: The primary objective of the Phase IIb portion of this study is to evaluate NaBen® (sodium benzoate) (1000 mg/day) safety and effectiveness and to determine the final sample...
Validation Study of the Aggression Diary
Principal Investigator: Findling, Robert
The primary objective of this study is to conduct psychometric tests on the electronic observer- reported (eObsRO) Aggression Diary to evaluate whether the diary is a valid and reliable measure for...
Activin Receptor-Based Therapies for Musculoskeletal Disease
Principal Investigator: Germain-Lee, Emily
Sponsored by the National Institute of Arthritis and Musculoskeletal and Skin Disease -- 1R01AR062074-04 The overall goal of this project is to investigate the role of the myostatin/activin signaling...
Phase 2 of Growth Hormone for Treatment of Albright Hereditary Osteodystrophy
Principal Investigator: Germain-Lee, Emily
Sponsored by the Food and Drug Administration -- 5R01FD003409-02. Albright hereditary osteodystrophy (AHO) is a rare genetic disorder caused by heterozygous inactivating mutations in the gene...
Osteogenesis Imperfecta Clinic
Principal Investigator: Germain-Lee, Emily
Sponsored by the Harry Headley Charitable & Research Foundation. Funding for an independent clinician/researcher to work with Dr. Jay Shapiro in the OI Clinic.
Retrospective Chart Review of Growth in Osteogenesis Imperfecta
Principal Investigator: Germain-Lee, Emily
The purpose of this research is to assess the growth parameters(height and weight) in osteogenesis imperfecta during infancy, childhood, and adolescence with the ultimate goal of determining whether...
Reward System in Autism
Principal Investigator: Goldberg, Melissa
It is a core feature of autism that social interactions appear to be far less rewarding for autistic children compared to typically developing children. Based on this observation, one would predict...
An evaluation of differential reinforcement on appropriate toy skills
Principal Investigator: Gonzales, Melissa
The purpose of the current study will be to increase the play skills for six children with developmental disabilities, who display limited interest in toys in a free operant setting. It is...
Delineating subtypes of self-injurious behavior maintained by automatic reinforcement
Principal Investigator: Hagopian, Louis
Self-injurious behavior (SIB) is one of the most serious problems experienced by individuals with intellectual disabilities. The standard of care for the assessment of SIB involves conducting a "...
Quantitative mapping of the basal ganglia and related structures in children with dyskinetic cerebral palsy
Principal Investigator: Hoon, Alexander
Cerebral palsy (CP) refers to a group of motor-impairment syndromes secondary to genetic and acquired disorders of early brain development.  When the underlying disorder affects the basal...