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Autism Spectrum Disorder in Down Syndrome: A Model of Repetitive and Stereotypic Behavior for Idiopathic ASD
The proposed project will be an initial delineation of the distinctive and specific features of Down syndrome (DS) and co-morbid Autism Spectrum Disorder (DS+ASD). The primary focus is on the characterization of the cognitive and behavioral profile of ASD and its differentiation from Stereotypic Movement Disorder (SMD) in DS boys. A secondary general hypothesis is that DS+ASD has a distinctive genetic/molecular profile that relates to its unique neurobehavioral features. We will collect blood samples and store them for future isolation of serum and lymphocytes. We plan to test this secondary hypothesis in future studies due to the complexity and expense of the necessary analyses.