Funded Research Projects

MCH Research - Parent-Mediated Vs. Center-Based Intervention for Toddlers with ASD: An RCT
Principal Investigator: Landa, Rebecca
An ever increasing number of toddlers are identified as being at high risk for ASD. This translates into an increasing demand for Part C Early Intervention services. The importance of intervention...
Effects of Self-Generated Experiences on Social Cognitive Development in Young Children with Autism
Principal Investigator: Landa, Rebecca
Sponsored by Autism Speaks -- 7746. This study will test whether a novel treatment for social impairment in young children with autism spectrum disorders (ASD) leads to improvement at behavioral and...
Development of a Social and Communication Intervention for Preschoolers with Autism
Principal Investigator: Landa, Rebecca
RFA topic and goal:  Autism Spectrum Disorders, Development and Innovation Goal Two Purpose:  Develop and document feasibility and promise of a social and communication curriculum, and...
Suppression of Glioblastoma Stem Cells by Kruppel-Like Factor 9
Principal Investigator: Laterra, John
Glioblastoma stem-like cells (or cancer stem cells, CSCs) maintain a capacity for multi-lineage differentiation and efficiently propagate tumor xenografts that accurately recapitulate the complex...
Brain Cancer Stem Cell Reprogramming by C-MET
Principal Investigator: Laterra, John
Glioblastoma (GBM) is an almost universally fatal brain tumor with an average median survival of only ~15 months. New effective therapies are desperately needed. Small subpopulations of malignant...
Accelerating Autism Research
Principal Investigator: Law, Paul
The proposed project will enable the Interactive Autism Network (IAN) to provide recruitment assistance to qualified research projects throughout the U.S. and to provide a large, validated...
Neuroimaging, Behavior, and Biochemical Correlates in Smith-Lemli-Opitz Syndrome (SLOS)
Principal Investigator: Lee, Ryan
SLOS is an autosomal recessive, multiple malformation syndrome of impaired cholesterol biosynthesis resulting in decreased cholesterol and elevated concentrations of abnormal sterols in tissues and...
Interactive Autism Network Project
Principal Investigator: Lipkin, Paul
The Interactive Autism Network (IAN) was established in 2006 to accelerate autism spectrum disorder (ASD) related research by creating a national online registry and longitudinal research...
Monitoring Prodrug Delivery in Suicide Gene Therapy Using CEST MRI
Principal Investigator: Liu, Guanshu
To accelerate the development of nanotechnologies for drug and gene delivery, it is highly desired to construct nanoparticles with imaging capabilities so that the process of delivery and release can...
Development of ADHD in Preschool Children: Neuroimaging and Behavioral Correlates
Principal Investigator: Mahone, E. Mark
Attention-Deficit/Hyperactivity Disorder (ADHD) has become the most commonly diagnosed form of psychopathology in the preschool years. To address this alarming trend, the overall goal of the proposed...
Optic Nerve Head Synucleinopathy in Glaucoma and Function of Gamma-Synuclein
Principal Investigator: Marsh-Armstrong, Nicholas
The broad long-term goal of this application is to uncover the mechanism of retinal ganglion cell (RGC) degeneration in glaucoma so as to be able to design rational therapeutic interventions based on...
Transcellular Degradation of Mitochondria in the Central Nervous System
Principal Investigator: Marsh-Armstrong, Nicholas
We recently made the surprising discovery that mitochondria from retinal ganglion cell axons are passed onto neighboring astrocytes for degradation in the optic nerve head of normal mice. We present...
Advanced Restoration Therapies in Spinal Cord Injury 0186 - FY 08 - 09
Principal Investigator: McDonald, John
Evidence suggests that functional electrical stimulation (FES) can improve certain functions in the central nervous system (CNS) following injury or disease. Using FES-based therapies in spinal cord...
Developing New Multicolor Polypeptide MR Contrast Agents for Stem Cell Tracking
Principal Investigator: McMahon, Michael
Development of new contrast materials is important to expand the diagnostic capabilities of MR at the cellular and molecular level. In particular, providing information on cell migration, trafficking...
Multi-Color Exchange Transfer Imaging of Drug Delivery Nanocarriers
Principal Investigator: McMahon, Michael
This project focuses on the design of biodegradable contrast agents, based on peptides and heterocycles, to be used for the labeling of drug delivery vehicles such as liposomes and polymeric...
OIACEST Islet Cell Capsules for Immunoprotection, MR Detection, and pH Sending
Principal Investigator: McMahon, Michael
Good glycemic control is critical in reducing the end-stage complications of Type I Diabetes Mellitus (TIDM) and, for this reason, islet transplantation (ITx) has received considerable attention in...
Anomalus Motor Physiology in ADHD
Principal Investigator: Mostofsky, Stewart
The hypothesis of this study is that the neuromotor anomalies present in children with ADHD will be associated with deficient intracortical and interhemispheric inhibition of the motor cortex. This...
Neurology of Deficient Response Control in ADHD
Principal Investigator: Mostofsky, Stewart
Building on evidence established in the initial grant period, the overall goals of the proposed study, “Neurology of Deficient Response Control in ADHD,” are to apply advanced neuroimaging and...
Motor Skill Learning in Autism
Principal Investigator: Mostofsky, Stewart
Abnormalities on motor examination have often afforded valuable insights into developmental disorders of the brain; such abnormalities have been well documented in individuals with autism and, in...
Pathogenesis of Rett Syndrome
Principal Investigator: Naidu, SakkuBai
This is an observational study of the natural history and clinical course of Rett Syndrome (RTT), a neurodevelopmental disorder primarily affecting females, caused by mutations in the MeCP2 gene. Our...
Placebo-Controlled Trial of Dextromethorphan in Rett Syndrome
Principal Investigator: Naidu, SakkuBai
The overall goal of this study is to counter the effects of increased N-methyl-D-aspartate (NMDA)/glutamate receptors in MeCP2-mutation-positive Rett syndrome (RTT) subjects by use of a placebo-...
Understanding the Brain Basis of Impaired Imitation Learning in Autism
Principal Investigator: Nebel, Mary Beth
In a developmental disorder such as autism (ASD), brain-based learning mechanisms vital to the acquisition of motor skills may contribute to impaired development of social and communicative abilities...
The Role of the Transcallosal Pathway in Neuroplasticity Following Nerve Injury
Principal Investigator: Pelled, Galit
Peripheral nerve injury causes sensory dysfunctions that are thought to be attributable not only to the functional, cellular and biochemical events occurring in the peripheral nerve, but also to the...
Adaptive Control of Epileptic Seizures Using A Genetically Encoded Sensor
Principal Investigator: Pelled, Galit
Sponsored by the National Institutes of Health (NIH) -- 1R01NS079288-01. About 35 percent of epileptic patients do not respond to antiepileptic drugs. Of these, only a quarter of them can be treated...
MRI-based Quantitative Brain Perfusion Mapping for Sickle Cell Disease
Principal Investigator: Qin, Qin
SCD is a genetic blood disorder characterized by abnormal hemoglobin S (HbS) synthesis with sickle cell anemia (SCA) as the most common subtype. Stroke is the most frequent cause of death and long-...