HUGO MOSER RESEARCH INSTITUTE OVERVIEW

Kennedy Krieger’s scientists and researchers are leaders in the worldwide effort to prevent and treat disorders of the brain, spinal cord, and musculoskeletal system.  Our investigators continue to break new ground with innovative magnetic resonance imaging technology, investigate critical areas, such as the role of genetics in developmental disorders, and develop new treatment models and therapies. Kennedy Krieger is committed to sharing our knowledge that can be adapted and used by other healthcare organizations to benefit patients across the country and around the world.

Professional Training Overview

Kennedy Krieger dedicates substantial resources to increasing the number of qualified specialists in the fields of neurological and developmental disabilities. We also take seriously our responsibility not only to improve care through research, but to share that knowledge with others. That is why more than 400 individuals come here to train in a wide variety of disciplines each year. The goals of the Institute’s clinical training programs are twofold: 1) to train leaders in the field of neurodevelopmental disabilities and 2) to help ensure that there is a sufficient number of qualified professionals to meet the needs of children with special health care needs and their families. By training future generations of researchers and professionals – from undergraduate students to current staff – we are ensuring that children everywhere can receive the best possible care.

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A National Research Resource Center for Functional Brain Imaging Technology

The only children's hospital designated as a NIH National Research Resource for functional brain imaging, Kennedy Krieger is breaking new ground with innovative fMRI technology.
Understanding Behaviors Through Observational Research

Discovering the environmental and biological basis of behavior is crucial to understanding and improving treatment outcomes for a wide variety of developmental disorders.
Motion Analysis Research and Laboratory

Using 3D modeling and other innovative technologies, our researchers are studying new methods to improve walking patterns in those with brain injuries.
IAN Research: Advancing Research, Empowering Advocates, Interpreting Findings

The Interactive Autism Network (IAN) is the nation's largest online autism research effort. IAN Research collects data from families online and matches them to studies nationwide.

HUGO MOSER RESEARCH INSTITUTE OVERVIEW

Kennedy Krieger’s scientists and researchers are leaders in the worldwide effort to prevent and treat disorders of the brain, spinal cord, and musculoskeletal system.  Our investigators continue to break new ground with innovative magnetic resonance imaging technology, investigate critical areas, such as the role of genetics in developmental disorders, and develop new treatment models and therapies. Kennedy Krieger is committed to sharing our knowledge that can be adapted and used by other healthcare organizations to benefit patients across the country and around the world.

Participate in Research

Over the years, Kennedy Krieger’s scientists and researchers have made crucial medical discoveries that have led to innovative treatments and improved patient care for individuals with disorders of the brain, spinal cord and musculoskeletal system. Learn more about current research studies you can participate in by visiting our recruiting research studies page. Learn more.

Current Research Projects

Mechanisms and Rehabilitation of Cerebellar Ataxia
Principal Investigator: Bastian, Amy
Sponsored by the National Institutes of Health -- 2R01HD040289. Cerebellar damage disrupts movement coordination. Actions ranging from walking to reaching become inaccurate and difficult to control,...
Human Locomotor Plasticity in Health and Disease
Principal Investigator: Bastian, Amy
Sponsored by the National Institutes of Health -- 5R01HD048741-06. Walking patterns can adapt on short timescales (minutes to hours) to temporary conditions, such as icy sidewalks. They can also...
Kennedy Krieger Family Center - Integrated Trauma Approaches
Principal Investigator: Belcher, Harolyn
The goals of the Kennedy Krieger Family Center Trauma Intervention Program (TIP) are to: Evaluate the feasibility and effectiveness of evidence-based treatment protocols, endorsed by the National...
Maternal Child Health Careers/Research Initiatives -- Undergraduate Program
Principal Investigator: Belcher, Harolyn
Sponsored by DHHS/CDC -- 1U50MN000025. Healthy People 2020 highlights the importance of eliminating health disparities and increasing the quality and years of healthy life free of preventable disease...
Differentiation of Fibroblast-Derived Induced Pluripotent Cells into Oligodendrocytes for Treatment of Neurological Disorders
Principal Investigator: Belegu, Visar
The isolation of human embryonic stem cells (hSECs) and the development of protocols to differentiate these cells toward various lineages are revolutionizing regenerative medicine. Transplantation of...
A 12 Week Double Blind Placebo Clinical Trial to Evaluate the Safety and Efficacy of Rivastigimine in Children with Down Syndrome
Principal Investigator: Capone, George
Individuals with Down syndrome (DS) exhibit a notable cholinergic deficiency by the 4th decade of life. It is unclear how early in life presynaptic cholinergic deterioration begins or how it evolves...
Translational Analyses of Chronic Aberrant Behavior Across the Lifespan
Principal Investigator: Cataldo, Michael
The goal of the proposed line of research is to gain a better understanding of the processes that evoke and maintain severe problem behavior (i.e., chronic aberrant behavior) in persons with...
Intellectual and Developmental Disabilities Research Centers 2008
Principal Investigator: Cataldo, Michael
This application for continued support of Years 21 through 25 of the Mental Retardation and Developmental Disabilities Research Center (MRDDRC) at the Kennedy Krieger Institute and Johns Hopkins...
Anticonvulsants, Ischemic Seizures and Regeneration in the Immature Brain
Principal Investigator: Comi, Anne
Neonatal stroke affects one in 4000 term births and frequently results in cognitive impairments. Neonatal strokes present with seizures, and anticonvulsants (usually phenobarbital) are administered...
Behavioral Economics in MR/DD and Behavior Disorders (2)
Principal Investigator: DeLeon, Iser
Assessments of severe behavior disorders of children with intellectual and developmental disabilities (IDD) have revealed that behavior problems are often maintained by their functional outcomes (or...
EEG-Based Assessment of Functional Connectivity in Autism
Principal Investigator: Ewen, Joshua
Sponsored by the National Institutes of Health -- 1K23NS073626-01. There are substantial data to suggest that altered cerebral connectivity is a key aspect of the neurobiology of autism. Nevertheless...
Study of White Matter Development in a Rodent Model of Perinatal Brain Injury
Principal Investigator: Fatemi, S. Ali
This is a Mentored Clinical Scientist Research Career Development Award allowing Dr. Fatemi to develop a career as an independent investigator in the field of translational neuroscience research,...
Comprehensive Long-Term Evaluation of the Gunn Rat Kernicterus Model
Principal Investigator: Fatemi, Seyed A.
The proposed project is the initial phase of a long-term endeavor to develop therapies that will help patients with dyskinetic cerebral palsy related to mitochondrial dysfunction and a Kernicterus-...
Mentored Clinical Scientist Research Career Development Award
Principal Investigator: Fatemi, Seyed A.
The proposed training will prepare a young pediatric neurology faculty member for a career as an independent investigator in the field of translational neuroscience research, focusing on perinatal...
Activin Receptor-Based Therapies for Musculoskeletal Disease
Principal Investigator: Germain-Lee, Emily
Sponsored by the National Institute of Arthritis and Musculoskeletal and Skin Disease -- 1R01AR062074-04 The overall goal of this project is to investigate the role of the myostatin/activin signaling...
Phase 2 of Growth Hormone for Treatment of Albright Hereditary Osteodystrophy
Principal Investigator: Germain-Lee, Emily
Sponsored by the Food and Drug Administration -- 5R01FD003409-02. Albright hereditary osteodystrophy (AHO) is a rare genetic disorder caused by heterozygous inactivating mutations in the gene...
Osteogenesis Imperfecta Clinic
Principal Investigator: Germain-Lee, Emily
Sponsored by the Harry Headley Charitable & Research Foundation. Funding for an independent clinician/researcher to work with Dr. Jay Shapiro in the OI Clinic.
Delineating subtypes of self-injurious behavior maintained by automatic reinforcement
Principal Investigator: Hagopian, Louis
Self-injurious behavior (SIB) is one of the most serious problems experienced by individuals with intellectual disabilities. The standard of care for the assessment of SIB involves conducting a "...
Quantitative mapping of the basal ganglia and related structures in children with dyskinetic cerebral palsy
Principal Investigator: Hoon, Alexander
Cerebral palsy (CP) refers to a group of motor-impairment syndromes secondary to genetic and acquired disorders of early brain development.  When the underlying disorder affects the basal...
Neurotrophin Protection of Hypoxic Ischemic Brain Injury
Principal Investigator: Hossain, Mir Ahamed
Perinatal hypoxia-ischemia (HI) is a major cause of life-long neurological disability such as cerebral palsy. There are few treatments available for this devastating disorder. For the next period of...
Functional and Neurovascular Biomarkers for Huntington’s disease using MRI at 7T
Principal Investigator: Hua, Jun
Oxidative stress and metabolic disturbances in the brain are believed to be involved in HD pathogenesis. Functional and neurovascular brain changes may represent altered neuronal physiology and...
Research Training in Rehabilitation for Brain Injury and Neurological Disability
Principal Investigator: Johnston, Michael
This is the first resubmission of an application for renewal of an Institutional National Research Service Award for a successful postdoctoral training program in medical rehabilitation research that...
Cholesterol Homeostasis in Malignant Glioma
Principal Investigator: Kolar, Elizabeth
The Watkins Lab has observed that when U87 human malignant glioma cells are deficient for a particular acyl- CoA synthetase, ACSVL3, the cells had significantly lower cholesterol levels than did wild...
Multisite RCT of Early Intervention for Spoken Communication in Autism
Principal Investigator: Landa, Rebecca
While significant progress has been made toward identifying effective interventions for preschool-age children with autism (National Research Council, 2001), few scientifically rigorous studies have...
Autism: Social and Communication Predictors in Siblings
Principal Investigator: Landa, Rebecca
This is a longitudinal study of Autism Spectrum Disorders (ASD). Six groups will be assessed longitudinally. Group 1: siblings of probands with autism; (Group 2) late talkers having no family history...
Role of acyl-CoA synthetases in lymphangioleiomyomatosis (LAM)
Principal Investigator: Watkins, Paul
LAM is characterized by proliferation of smooth muscle cells in the lung. SLC27A3 is an acyl-CoA synthetase whose activity seems to be increased in rapidly proliferating cells. The fundamental...
Evaluation of Child, Parent and Physician Characteristics Associated with Complementary and Alternative Medicine Use in Children with Autism Spectrum Disorders
Principal Investigator: Wilms-Floet, Anna Maria
Our research plan is to identify child-, parent- and clinician characteristics that are associated with CAM use, using de-identified, retrospective data from the Autism Treatment Network Registry (...
Differences in Behavioral and Adaptive Profiles among Children Diagnosed with Autism Spectrum Disorders, Attention-Deficit/Hyperactivity Disorder, or Anxiety Disorder
Principal Investigator: Wodka, Erica
This study is a retrospective review of assessment data from routine psychological or neuropsychological evaluations. The focus of this study is to examine behavioral and adaptive profiles of...
Ecological validity of neuropsychological testing and screening
Principal Investigator: Zabel, Andrew
Neuropsychological assessment and screening is a useful means of identifying cognitive deficits in children and adolescents. Expansion of availability of instruments has now permitted an examination...
Evaluation of data obtained from a Phase III trial to evaluate Lorenzo's oil in adults with X-linked adrenoleukodystrophy
Principal Investigator: Zackowski, Kathleen
This study will evaluate data collected in a placebo-controlled study of Lorenzo's oil in adult men and women with X-linked adrenoleukodystrophy. This study was originally run from 2005-2008 under Dr...

Faculty & Research Scientists