Lisa Kratz, M.D., Ph.D.

Lisa Kratz
Lisa Kratz
Director, Biochemical Genetics Laboratory

Kennedy Krieger Institute
707 N. Broadway
Baltimore, MD 21205
Phone: (443) 923-2782

Dr. Lisa Kratz is the director of the Biochemical Genetics Laboratory at Kennedy Krieger Institute and an assistant professor of pediatrics at Johns Hopkins Hospital. 

Biographical Sketch:

Dr. Kratz received her bachelor's of arts from Western Maryland College in 1985, and her doctorate in human genetics from the University of Maryland at Baltimore in 1989. She completed a post-doctoral fellowship in biochemical genetics at University of Colorado Health Sciences Center in 1991, and was the assistant director of the biochemical diseases detection laboratory at Yale University from 1991 to 1993. In 1993, Dr. Kratz became board certified in biochemical genetics. She has been with the Kennedy Krieger Institute since 1993. Dr. Kratz is a member of the American Society of Human Genetics and the Society For Inherited Metabolic Disorders.

Research Summary:

Dr. Kratz's interests focus on the diagnosis of certain inborn errors of metabolism and clinical research related to these disorders. One area of interest involves disorders of cholesterol biosynthesis including Smith-Lemli-Opitz syndrome, Desmosterolosis, X-Linked Dominant Conradi Hünermann Syndrome, and CHILD sequence . Other areas of interest include disorders of creatine synthesis and transport, Barth syndrome, and Mevalonate Kinase deficiency.

LINK: SciVal Experts Research Profile for Lisa Kratz

Research Publications

Sukhanova A, Gorin A, Serebriiskii IG, Gabitova L, Zheng H, Restifo D, Egleston BL, Cunningham D, Bagnyukova T, Liu H, Nikonova A, Adams GP, Zhou Y, Yang DH, Mehra R, Burtness B, Cai KQ, Klein-Szanto A, Kratz LE, Kelley RI, Weiner LM, Herman GE, Golemis EA, Astsaturov I. (2013). Targeting C4-demethylating genes in the cholesterol pathway sensitizes cancer cells to EGF receptor inhibitors via increased EGF receptor degradation. Cancer Discovery, 3(1), 96-111.

Gauthier N, Wu JW, Wang SP, Allard P, Mamer OA, Sweetman L, Moser AB, Kratz L, Alvarez F, Robitaille Y, Lépine F, Mitchell GA. (2013). A liver-specific defect of Acyl-CoA degradation produces hyperammonemia, hypoglycemia and a distinct hepatic Acyl-CoA pattern. PLoS One, 8(7), e60581.

Herman GE, Kratz L. (2012). Disorders of sterol synthesis: beyond Smith-Lemli-Opitz syndrome. American Journal of Medical Genetics. Part C, Seminars in Medical Genetics, 160C(4), 301-321.

Clark PJ, Thompson AJ, Vock DM, Kratz LE, Tolun AA, Muir AJ, McHutchison JG, Subramanian M, Millington DM, Kelley RI, Patel K. (2012). Hepatitis C virus selectively perturbs the distal cholesterol synthesis pathway in a genotype-specific manner. Hepatology, 56(1), 49-56.

Schaaf CP, Koster J, Katsonis P, Kratz L, Shchelochkov OA, Scaglia F, Kelley RI, Lichtarge O, Waterham HR, Shinawi M. (2011). Desmosterolosis-phenotypic and molecular characterization of a third case and review of the literature. American Journal of Medical Genetics. Part A, 155A(7), 1597-1604.

Stottmann RW, Turbe-Doan A, Tran P, Kratz LE, Moran JL, Kelley RI, Beier DR. (2011). Cholesterol metabolism is required for intracellular hedgehog signal transduction in vivo. PLoS Genetics, 7(9), e1002224.

He M, Kratz LE, Michel JJ, Vallejo AN, Ferris L, Kelley RI, Hoover JJ, Jukic D, Gibson KM, Wolfe LA, Ramachandran D, Zwick ME, Vockley J. (2011). Mutations in the human SC4MOL gene encoding a methyl sterol oxidase cause psoriasiform dermatitis, microcephaly, and developmental delay. The Journal of Clinical Investigation, 121(3), 976-984.

Pei W, Kratz LE, Bernardini I, Sood R, Yokogawa T, Dorward H, Ciccone C, Kelley RI, Anikster Y, Burgess HA, Huizing M, Feldman B. (2010). A model of Costeff Syndrome reveals metabolic and protective functions of mitochondrial OPA3. Development, 137(15), 2587-2596.

Correa-Cerro LS, Wassif CA, Kratz L, Miller GF, Munasinghe JP, Grinberg A, Fliesler SJ, Porter FD. (2006). Development and characterization of a hypomorphic Smith-Lemli-Opitz syndrome mouse model and efficacy of simvastatin therapy. Human Molecular Genetics, 15(6), 839-851.