S. Ali Fatemi, M.D.

S. Ali Fatemi, MD
S. Ali Fatemi
Pediatric Neurologist, Division of Neurology and Developmental Medicine

Kennedy Krieger Institute
707 N. Broadway
Baltimore, MD 21205
Phone: (443) 923-9150
Email: fatemi@kennedykrieger.org

S. Ali Fatemi, MD, is a pediatric neurologist at the Division of Neurology and Developmental Medicine, and an investigator at the Hugo W. Moser Research Institute at Kennedy Krieger. Dr. Fatemi is also an assistant professor of neurology at Johns Hopkins University.

Biographical Sketch:

Dr. Fatemi received his medical degree from the Medical University of Vienna, Austria in 1999. After graduation, he served as a researcher and lecturer at the Institute for Medical Chemistry in Vienna and completed an internship in pediatrics at the Vienna General Hospital. He was recruited by Dr. Hugo W. Moser as a post-doctoral fellow in neurogenetics and neuroimaging research at Kennedy Krieger Institute in 2001. During this initial period at Kennedy Krieger Institute, Dr. Fatemi collaborated with a team of scientists and developed new imaging methods in patients with leukodystrophies, a group of rare genetic diseases that affect the brain's white matter and coordinated an internet-2 based imaging network for these diseases. He then left Kennedy Krieger Institute to train in general pediatrics and then completed a child neurology residency at the Massachusetts General Hospital, an affiliate of Harvard Medical School, in Boston. Dr. Fatemi has returned to the Kennedy Krieger Institute in 2008 as a faculty member.

He is a member of the Child Neurology Society, the International Child Neurology Association, the Society for Neuroscience, the American Academy of Neurology and the International Society for Magnetic Resonance in Medicine. He has served as ad hoc reviewer for the Journals Child Development and American Journal of Neuroradiology.

At the Kennedy Krieger outpatient center, Dr. Fatemi evaluates children with a variety of neurologic problems. His greatest interest is in genetic and acquired conditions that affect the brain's white matter in newborns and infants, these include white matter injury associated with extreme prematurity (also referred to as periventricular leukomalacia), as well as leukodystrophies

Research Summary:

The brain's white matter consists of axons, the "cables" that build up a complex network of connections between different neurons, these axons are wrapped by oligodendrocytes, cells that produce a thick membrane, referred to as myelin, which is important for the isolation and protection of axons. Another group of cells, referred to as astrocytes, are also important constituents of white matter and serve as gatekeepers for nutrients that enter the brain and play a role in brain metabolism. Disorders of white matter can either affect the axon, the oligodendrocyte, or the astroycte. Perinatally acquired white matter injury is the leading cause of cerebral palsy and other neuropsychiatric conditions in children born prematurely.

Dr. Fatemi is a member of the neuroscience laboratory and the F.M. Kirby Research Center for functional Brain Imaging. He collaborates closely with a multi-disciplinary group of scientists at the Hugo W. Moser Research Institute and at Johns Hopkins to study the molecular mechanism involved in white matter development and injury in mouse models for cerebral palsy and perinatal white matter injury. Dr. Fatemi and his colleagues utilize different molecular, histological and advanced magnetic resonance imaging (MRI) techniques to examine rodents.

In addition, there is a strong effort at the neuroscience laboratory to use animal models as a test bed for cell-based therapeutic approaches. Stem cells and progenitor cells are derived from mouse embryos and Dr. Fatemi and his colleagues are currently evaluating if transplanted cells are able to survive in the injured animals, migrate to the desired site, and eventually restore white matter injury either by differentiation into more mature cells or by providing support to the injured tissue.

Dr. Fatemi is also a member of the Neurogenetics Research Center at Kennedy Krieger and is involved in clinical and imaging research studies of patients with X-linked adrenoleukodystrophy.

Research Publications

Phillips AW, Johnston MV, Fatemi A. (2013). The potential for cell-based therapy in perinatal brain injuries. Translational Stroke Research, 4(2), 137-148.

Verina T, Fatemi A, Johnston MV, Comi AM. (2013). Pluripotent possibilities: human umbilical cord blood cell treatment after neonatal brain injury. Pediatric Neurology, 48(5), 346-354.

Lee RW, Bodurtha J, Cohen J, Fatemi A, Batista D. (2013). Deletion 12p12 involving SOX5 in two children with developmental delay and dysmorphic features. Pediatric Neurology, 48(4), 317-320.

Falahati S, Breu M, Waickman AT, Phillips AW, Arauz EJ, Snyder S, Porambo M, Goeral K, Comi AM, Wilson MA, Johnston MV, Fatemi A. (2013). Ischemia-induced neuroinflammation is associated with disrupted development of oligodendrocyte progenitors in a model of periventricular leukomalacia. Developmental Neuroscience, 35(2-3), 182-196.

Paciorkowski AR, Traylor RN, Rosenfeld JA, Hoover JM, Harris CJ, Winter S, Lacassie Y, Bialer M, Lamb AN, Schultz RA, Berry-Kravis E, Porter BE, Falk M, Venkat A, Vanzo RJ, Cohen JS, Fatemi A, Dobyns WB, Shaffer LG, Ballif BC, Marsh ED. (2013). MEF2C Haploinsufficiency features consistent hyperkinesis, variable epilepsy, and has a role in dorsal and ventral neuronal developmental pathways. Neurogenetics, 14(2), 99-111.

Phillips AW, Falahati S, DeSilva R, Shats I, Marx J, Arauz E, Kerr DA, Rothstein JD, Johnston MV, Fatemi A. (2012). Derivation of glial restricted precursors from E13 mice. Journal of Visualized Experiements, 64, pii: 3462.

Poretti A, Blaser SI, Lequin MH, Fatemi A, Meoded A, Northington FJ, Boltshauser E, Huisman TA. (2013). Neonatal neuroimaging findings in inborn errors of metabolism. Journal of Magnetic Resonance Imaging, 37(2), 294-312.

Fatemi A, Wilson MA, Phillips AW, McMahon MT, Zhang J, Smith SA, Arauz EJ, Falahati S, Gummadavelli A, Bodagala H, Mori S, Johnston MV. (2011). In vivo magnetization transfer MRI shows dysmyelination in an ischemic mouse model of periventricular leukomalacia. Journal of Cerebral Bloof Flow and Metablolism, 31(10), 2009-2018.

Johnston MV, Fatemi A, Wilson MA, Northington F. (2011). Treatment advances in neonatal neuroprotection and neurointensive care. The Lancet. Neurology. 10(4), 372-382.

Fatemi A, Wilson MA, Johnston MV. (2009). Hypoxic-ischemic encephalopathy in the term infant. Clinics in Perinatology, 36(4), 835-858.

Smith SA, Golay X, Fatemi A, Mahmood A, Raymond GV, Moser HW, van Zijl PC, Stanisz GJ. (2009). Quantitative magnetization transfer characteristics of the human cervical spinal cord in vivo: application to adrenomyeloneuropathy. Magnetic Resonance in Medicine, 61(1), 22-27.

Dubey P, Fatemi A, Huang H, Nagae-Poetscher L, Wakana S, Barker PB, van Zijl P, Moser HW, Mori S, Raymond GV. (2005). Diffusion tensor-based imaging reveals occult abnormalities in adrenomyeloneuropathy. Annals of Neurology, 58(5), 758-766.

Fatemi A, Smith SA, Dubey P, Zackowski KM, Bastian AJ, van Zijl PC, Moser HW, Raymond GV, Golay X. (2005). Magnetization transfer MRI demonstrates spinal cord abnormalities in adrenomyeloneuropathy. Neurology, 64(10), 1739-1745.

Dubey P, Fatemi A, Barker PB, Degaonkar M, Troeger M, Zackowski K, Bastian A, Smith SA, Pomper MG, Moser HW, Raymond GV. (2005). Spectroscopic evidence of cerebral axonopathy in patients with "pure" adrenomyeloneuropathy. Neurology, 64(2), 304-310.

Dubey P, Fatemi A, Huang H, Nagae-Poetscher L, Wakana S, Barker PB, van Zijl P, Moser HW, Mori S, Raymond GV. (2005). Diffusion tensor-based imaging reveals occult abnormalities in adrenomyeloneuropathy. Annals of Neurology, 58(5), 758-766.

Smith SA, Golay X, Fatemi A, Jones CK, Raymond GV, Moser HW, van Zijl PC. (2005). Magnetization transfer weighted imaging in the upper cervical spinal cord using cerebrospinal fluid as intersubject normalization reference (MTCSF imaging). Magnetic Resonance in Medicine, 54(1), 201-2016

Nagae-Poetscher LM, McMahon M, Braverman N, Lawrie WT Jr, Fatemi A, Degaonkar M, Horská A, Pomper MG, Chacko VP, Barker PB. (2004). Metabolites in ventricular cerebrospinal fluid detected by proton magnetic resonance spectroscopic imaging. Journal of Magnetic Resonance Imaging, 20(3), 496-500.

Moser H, Dubey P, Fatemi A. (2004). Progress in X-linked adrenoleukodystrophy. Current Opinion in Neurology, 17(3), 263-269.

Moser HW, Fatemi A, Zackowski K, Smith S, Golay X, Muenz L, Raymond G. (2004). Evaluation of therapy of X-linked adrenoleukodystrophy. Neurochemical Research, 29(5), 1003-1016.

Nagae-Poetscher LM, Bibat G, Philippart M, Rosemberg S, Fatemi A, Lacerda MT, Costa MO, Kok F, Costa Leite C, Horská A, Barker PB, Naidu S. (2004). Leukoencephalopathy, cerebral calcifications, and cysts: new observations. Neurology, 62(7), 1206-1209.