Marco A.

Grados

,

MD, MPH

Education

After completing his undergraduate and medical training in Lima, Peru, Dr. Grados came to Detroit for an internship in internal medicine and a residency in psychiatry at the Henry Ford Health Systems. He came to Baltimore in 1994 as child psychiatry fellow, chief resident in child psychiatry at Johns Hopkins and psychiatry faculty at Kennedy Krieger Institute. Dr. Grados also obtained a master's of public health (M.P.H.) in genetic epidemiology from the Johns Hopkins School of Public Health.

After six years as medical director of outpatient programs in the Institute's Department of Psychiatry, overseeing the outpatient care of child psychiatry outpatients, Dr. Grados is now dedicated to genetic epidemiology research in obsessive-compulsive disorder (OCD) and related disorders. He obtained a five-year Research Career Development Award from the National Institute of Mental Health (2002-2007) to study the genetics of OCD in children.

Research

Obsessive-compulsive disorder (OCD) is the fourth most common psychiatric disorder, affecting two to three percent of children and adolescents. It consists of intrusive ideas that are distressing and persistent (obsessions), or fixed behaviors that are compulsory in nature (compulsions). Examples are excessive handwashing, checking, perfectionism, touching, counting or hoarding. Dr. Grados has conducted a family study of OCD with child probands with the goal of locating susceptibility genes for OCD. As part of the the OCD Genetics Consortium (OCGS) based at Hopkins and the Tourette Syndrome Association International Genetics Consortium (TSA-IGC), Dr. Grados continues to investigate the genetic basis of OCD and Tourette syndrome (motor and vocal tics).

With support from the Obsessive-Compulsive Foundation (OCF), Dr. Grados also studies the subtype of "autoimmune OCD" collecting serum to test for cytokine network abnormalities (markers of inflammation) in children with OCD and Tourette syndrome. Dr. Grados also conducts research in a genetic syndrome, Cornelia de Lange syndrome (CdLS), with support from the CdLS-USA Foundation. CdLS provides a research model to better understand autism and obsessive-compulsive traits (repetitive behaviors) starting from a known gene mechanism.

Related Links

Elsevier Fingerprint Engine Profile for Marco Grados

Research Publications

Blom RM, Samuels JF, Riddle MA, Joseph Bienvenu O, Grados MA, Reti IM, Eaton WW, Liang KY, Nestadt G (2011). Association between a serotonin transporter promoter polymorphism (5HTTLPR) and personality disorder traits in a community sample. J Psychiatr Res. 45(9), 1153-9.

Samuels J, Wang Y, Riddle MA, Greenberg BD, Fyer AJ, McCracken JT, Rauch SL, Murphy DL, Grados MA, Knowles JA, Piacentini J, Cullen B, Bienvenu OJ 3rd, Rasmussen SA, Geller D, Pauls DL, Liang KY, Shugart YY, Nestadt G (2011). Comprehensive family-based association study of the glutamate transporter gene SLC1A1 in obsessive-compulsive disorder. Am J Med Genet B Neuropsychiatr Genet. 156B(4), 472-7. 

Mroczkowski MM, Goes FS, Riddle MA, Grados MA, Bienvenu OJ 3rd, Greenberg BD, Fyer AJ, McCracken JT, Rauch SL, Murphy DL, Knowles JA, Piacentini J, Cullen B, Rasmussen SA, Geller DA, Pauls DL, Liang KY, Nestadt G, Samuels JF (2011). Separation anxiety disorder in OCD. Depress Anxiety. 28(3), 256-62.

Turin E, Grados MA, Tierney E, Ferenc LM, Zabel A, Comi AM (2010). Behavioral and psychiatric features of Sturge-Weber syndrome. J Nerv Ment Dis. 198(12), 905-13.

Grados MA (2010). The genetics of obsessive-compulsive disorder and Tourette syndrome: an epidemiological and pathway-based approach for gene discovery. J Am Acad Child Adolesc Psychiatry. 49(8), 810-9, 819.e1-2.

Grados MA, Mathews CA (2009). Clinical phenomenology and phenotype variability in Tourette syndrome. J Psychosom Res. 67(6), 491-6. 

Gerring JP, Grados MA, Slomine B, Christensen JR, Salorio CF, Cole WR, Vasa RA (2009). Disruptive behaviour disorders and disruptive symptoms after severe paediatric traumatic brain injury. Brain Inj. 23(12), 944-55.

Gause C, Morris C, Vernekar S, Pardo-Villamizar C, Grados MA, Singer HS (2009). Antineuronal antibodies in OCD: comparisons in children with OCD-only, OCD+chronic tics and OCD+PANDAS. J Neuroimmunol. 214(1-2), 118-24.

Grados MA (2009). The genetics of obsessive-compulsive disorder and Tourette's syndrome: what are the common factors? Curr Psychiatry Rep. 11(2), 162-6.

Samuels JF, Bienvenu OJ, Pinto A, Murphy DL, Piacentini J, Rauch SL, Fyer AJ, Grados MA, Greenberg BD, Knowles JA, McCracken JT, Cullen B, Riddle MA, Rasmussen SA, Pauls DL, Liang KY, Hoehn-Saric R, Pulver AE, Nestadt G (2008). Sex-specific clinical correlates of hoarding in obsessive-compulsive disorder. Behav Res Ther. 46(9), 1040-6. 

Grados MA, Mathews CA, Tourette Syndrome Association International Consortium for Genetics (2008). Latent class analysis of gilles de la tourette syndrome using comorbidities: clinical and genetic implications. Biol Psychiatry. 64(3), 219-25.

Ginsburg GS, Kingery JN, Drake KL, Grados MA (2008). Predictors of treatment response in pediatric obsessive-compulsive disorder. J Am Acad Child Adolesc Psychiatry. 47(8), 868-78.

Samuels JF, Bienvenu OJ, Grados MA, Cullen B, Riddle MA, Liang KY, Eaton WW, Nestadt G(2008). Prevalence and correlates of hoarding behavior in a community-based sample.Behav Res Ther. 46(7), 836-44.

Cullen B, Samuels JF, Pinto A, Fyer AJ, McCracken JT, Rauch SL, Murphy DL, Greenberg BD, Knowles JA, Piacentini J, Bienvenu OJ 3rd, Grados MA, Riddle MA, Rasmussen SA, Pauls DL, Willour VL, Shugart YY, Liang KY, Hoehn-Saric R, Nestadt G (2008). Demographic and clinical characteristics associated with treatment status in family members with obsessive-compulsive disorder. Depress Anxiety. 25(3), 218-24.

Grados MA, Vasa RA, Riddle MA, Slomine BS, Salorio C, Christensen J, Gerring J (2008). New onset obsessive-compulsive symptoms in children and adolescents with severe traumatic brain injury. Depress Anxiety. 25(5), 398-407.

Salorio CF, Slomine BS, Guerguerian AM, Christensen JR, White JR, Natale JE, Shaffner DH, Grados MA, Vasa RA, Gerring JP (2008). Intensive care unit variables and outcome after pediatric traumatic brain injury: a retrospective study of survivors. Pediatr Crit Care Med. 9(1), 47-53.

Samuels JF, Bienvenu OJ 3rd, Pinto A, Fyer AJ, McCracken JT, Rauch SL, Murphy DL, Grados MA, Greenberg BD, Knowles JA, Piacentini J, Cannistraro PA, Cullen B, Riddle MA, Rasmussen SA, Pauls DL, Willour VL, Shugart YY, Liang KY, Hoehn-Saric R, Nestadt G(2007). Hoarding in obsessive-compulsive disorder: results from the OCD Collaborative Genetics Study. Behav Res Ther. 45(4), 673-86.

Samuels J, Shugart YY, Grados MA, Willour VL, Bienvenu OJ, Greenberg BD, Knowles JA, McCracken JT, Rauch SL, Murphy DL, Wang Y, Pinto A, Fyer AJ, Piacentini J, Pauls DL, Cullen B, Rasmussen SA, Hoehn-Saric R, Valle D, Liang KY, Riddle MA, Nestadt G (2007). Significant linkage to compulsive hoarding on chromosome 14 in families with obsessive-compulsive disorder: results from the OCD Collaborative Genetics Study. Am J Psychiatry. 164(3), 493-9.

Grados MA, Walkup JT (2006). A new gene for Tourette's syndrome: a window into causal mechanisms? Trends Genet. 22(6), 291-3.

Samuels JF, Riddle MA, Greenberg BD, Fyer AJ, McCracken JT, Rauch SL, Murphy DL, Grados MA, Pinto A, Knowles JA, Piacentini J, Cannistraro PA, Cullen B, Bienvenu OJ 3rd, Rasmussen SA, Pauls DL, Willour VL, Shugart YY, Liang KY, Hoehn-Saric R, Nestadt G(2006). The OCD collaborative genetics study: methods and sample description. Am J Med Genet B Neuropsychiatr Genet. 141B(3), 201-7.

Salorio CF, Slomine BS, Grados MA, Vasa RA, Christensen JR, Gerring JP (2005). Neuroanatomic correlates of CVLT-C performance following pediatric traumatic brain injury. J Int Neuropsychol Soc. 11(6), 686-96.

Slomine BS, Salorio CF, Grados MA, Vasa RA, Christensen JR, Gerring JP (2005). Differences in attention, executive functioning, and memory in children with and without ADHD after severe traumatic brain injury. J Int Neuropsychol Soc. 11(5), 645-53.

Capone GT, Grados MA, Kaufmann WE, Bernad-Ripoll S, Jewell A (2005). Down syndrome and comorbid autism-spectrum disorder: characterization using the aberrant behavior checklist. Am J Med Genet A. 134(4), 373-80.