This study is recruiting until 2026

Study Name: Anomalous Motor System Physiology in ADHD: Biomarker Validation and Modeling Domains of Function (IRB#: 00251063, Principal Investigator: Dr. Stewart Mostofsky, M.D.)

Funding: National Institute of Mental Health (Award #: 5R01MH078160-13)

Description: This research study investigates neural biomarkers (specific electrical signals in the motor area of the brain that control muscle movement and movement planning) associated with attention deficit/hyperactive disorder (ADHD). During the research appointments, participants complete an IQ assessment, questionnaires, computer games that assess cognitive skills, movement activities that assess balance and coordination, and two 2-hour sessions of transcranial magnetic stimulation (TMS).

Eligible Age Range: 8 years, 0 months and 12 years, 11 months

Time Commitment: Participation in this study requires two full day appointments (typically 8:30am-2:30pm).

Compensation: Earn up to $50 per day, MRI report and IQ report

Optional Component (For Participants with ADHD Only): Participants with ADHD can elect to complete an additional research appointment (typically 8:30am-2:30pm) that includes two additional sessions of TMS and taking a low dose (10 mg) of methylphenidate (also known as Ritalin). The purpose of this component is to assess the impact of stimulant medication on motor control. Participants complete their IQ testing, computer games, and movement activities during their first appointment. During their second and third appointments, participants complete a 2-hour TMS session in the morning, take either a placebo (sugar pill) or methylphenidate during a 1-hour lunch break, and complete a 2-hour TMS session in the afternoon. Children already taking stimulant medication withhold their medication on their appointment days. Participants with ADHD who elect to complete the medication component receive an additional $50.

Eligible Age Range: 8 years, 0 months through 12 years, 11 months

Contact Information: CNIR@KennedyKrieger.org

Study Keywords: Attention Deficit Hyperactivity Disorder, ADHD, neurotypical